Clinical study on Tanreqing Injection combined with tigecycline in treatment of hospital-acquired pneumonia
Objective To investigate the curative effect of Tanreqing Injection combined with Tigacycline for injection in treatment of hospital-acquired pneumonia. Methods A total of 85 patients with hospital-acquired pneumonia treated in the Second Affiliated Hospital of Tianjin University of Chinese Medicine from March 2022 to November 2023 were selected and divided into control group (42 cases) and treatment group (43 cases) according to random number table method. Patients in the control group were given intravenous Tigecycline for injection,the first dose of 100 mg,once daily,and then once every 12 h,50 mg/time,for 30 to 60 min. Patients in the treatment group were given Tanreqing Injection on the basis of control group,20 mL/time,once daily. Patients of two groups were treated for 10 d. The clinical efficacy,symptom disappearance time,disease degree,and serum indexes were compared between two groups. Results The total effective rate of patients in the treatment group was 95.35％,and that in the control group was 80.95％,and the difference between groups was significant (P<0.05). The disappearance time of high fever,cough,lung rales,and lung shadows in the treatment group was shorter than that in the control group (P<0.05). CPIS score in both groups were decreased significantly,and CPIS score of the treatment group was significantly lower than that in the control group (P<0.05). After treatment,the serum levels of TREM-1,ApoE,and PCT in both groups were lower than that before treatment (P<0.05),and the serum levels of TREM-1,ApoE,and PCT in the treatment group were lower than those in the control group (P<0.05). Conclusion Tanreqing Injection combined with Tigacycline for injection can improve the curative effect of hospital-acquired pneumonia,effectively control the disease,improve the efficiency of symptom improvement,and reduce the inflammatory reaction.
Tanreqing InjectionTigacycline for injectionhospital-acquired pneumonialung shadows disappearance timeCPIS scoreTREM-1ApoEPCT
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