Clinical study on Qingke Pingchuan Granules combine with fluticasone propionate in treatment of cough variant asthma in children
Objective To observe the clinical efficacy of Qingke Pingchuan Granules combine with Fluticasone Propionate Inhalation Aerosol in treatment of cough variant asthma in children. Methods A total of 136 children with cough variant asthma who were treated in Zigong First People's Hospital from May 2021 to January 2023 were selected and divided into the control group (68 cases) and the treatment group (68 cases) according to random number method. Children in the control group were given Fluticasone Propionate Inhalation Aerosol,50-100 μg/time,twice daily. Children in the treatment group were given Qingke Pingchuan Granules with boiling water on the basis of the control group,5-8 years old,6 g/times,9-14 years old,8 g/times,3 times daily. Children in both groups were treated continuously for 4 weeks. The clinical efficacy,pulmonary function index,inflammatory factor index,T lymphocyte subgroup index,and immunoglobulin index were compared between two groups. Results After treatment,the clinical control rate of the treatment group was 94.12％,which was higher than that of the control group 77.94％ (P<0.05). After treatment,FVC,FEV1,and PEF in both groups were increased (P<0.05),and FVC,FEV1,and PEF in treatment group were higher than those in control group (P<0.05). After treatment,the serum levels of IL-10 in two groups were increased,but the serum levels of IL-6 and MMP-9 in two groups were decreased (P<0.05). The serum level of IL-10 in the treatment group was higher than that in the control group,but the serum levels of IL-6 and MMP-9 in the treatment group were lower than those in the control group (P<0.05). After treatment,CD3+,CD4+,and CD4+/CD8+in two groups were increased,but CD8+were decreased (P<0.05),and CD3+,CD4+,and CD4+/CD8+in the treatment group was higher than that in the control group,but CD8+in the treatment was lower than that in the control group (P<0.05). After treatment,IgE,IgA,and IgG in the two groups were increased (P<0.05),and the immunoglobulin in the treatment group was higher than that in the control group (P<0.05). Conclusion Qingke Pingchuan Granules combined with Fluticasone Propionate Inhalation Aerosol in treatment of cough variant asthma in children can effectively improve the lung function,improve the immune function,and regulate the level of inflammatory factors.
Qingke Pingchuan GranulesFluticasone Propionate Inhalation Aerosolchildren with cough variant asthmaFVCFEV1PEFIL-10MMP-9IgE
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