Clinical study on Ganhai Weikang Capsules combined with amoxicillin and esomeprazole dual therapy regimen in treatment of peptic ulcers
Objective To investigate the curative effect of Ganhai Weikang Capsules combined with Amoxicillin Capsules and Esomeprazole Magnesium Enteric-coated Tablets in treatment of peptic ulcers. Methods 204 Patients with peptic ulcers admitted to Qingdao Eighth People's Hospital from December 2021 to June 2023 were divided into control group and a treatment group using a random number table method,with 102 patients in each group. Patients in the control group were treated with Amoxicillin Capsules,3 grains/time,4 times daily,for 14 d,and then stopped. Esomeprazole Magnesium Enteric-coated Tablets were taken orally,1 tablet/time,4 times daily,for 14 d,and then the maintenance dose was 1 tablet/time,once daily,for 2 weeks. Patients in the treatment group were given Ganhai Weikang Capsules,6 grains/time,3 times/day,for 4 weeks on the basis of control group. The clinical efficacy,gastroscopic efficacy,Helicobacter pylori negative conversion rate,duration of symptom remission,and serum factors of the two groups were compared. Results After treatment,the total effective rate of clinical efficacy in the treatment group (94.12％) was higher than that in the control group (85.29％),and the difference between groups was significant (P<0.05). After treatment,the total effective rate of gastroscopy efficacy in the treatment group (96.08％) was higher than that of the control group (87.25％),and the difference between groups was significant (P<0.05). After treatment,H. pylori negative conversion rate in the treatment group (96.08％) was higher than that in the control group (88.24％),and the difference between groups was significant (P<0.05). After treatment,the remission time of abdominal pain,heartburn,and acid reflux in treatment group was shorer than that in control group (P<0.05). After treatment,the serum levels of IL-17,TNF-α,and ET were significantly decreased in two groups (P<0.05),and the serum levels of IL-17,TNF-α,and ET in treatment group was greater than those in the control group (P<0.05). Conclusion Ganhai Weikang Capsules combined with Amoxicillin Capsules and Esomeprazole Magnesium Enteric-coated Tablets can improve the curative effect of peptic ulcers,increase the H. pylori negative conversion rate,promote the remission of symptoms,and reduce inflammation.
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