Objective To investigate the clinical efficacy of Anweiyang Capsules combined with Sucralfate Suspensoid Gel in treatment of gastric ulcer. Methods A total of 166 patients with gastric ulcer admitted to Bazhong Central Hospital from August 2021 to June 2023 were selected and divided into control group and treatment group according to random number table method,with 83 cases in each group. Patients in the control group were given Sucralfate Suspensoid Gel,1 g/time,1 time in the morning 1 h before meals and 1 time on an empty stomach before going to bed. Patients in the treatment group were po administered with Anweiyang Capsules on the basis of the control group,2 capsules/time,4 times daily,after three meals and before going to bed,with warm water. Both groups were treated for 6 weeks. The clinical efficacy of the two groups was observed,the typical symptom scores of the two groups were compared before and after treatment,and the ulcer healing rate and Helicobacter pylori (Hp) eradication rate were analyzed. The scores of 36 health survey Summary Form (SF-36),Symptom Checklist (SCL-90) and serum gastric function indexes[pepsinogen Ⅰ (Pⅰ),ratio of Pⅰ to pepsinogen Ⅱ (PGR),gastrin-17 (G-17)]and prostaglandin E2 (PGE2) before and after treatment were compared between two groups. Results After treatment,the total effective rate of the treatment group was 96.39％,which was significantly higher than that of the control group (87.95％,P<0.05). After treatment,the scores of upper abdominal pain,belching and acid reflux in 2 groups were significantly decreased (P<0.05). After treatment,the typical symptom score of treatment group was lower than that of the control group (P<0.05). After treatment,the ulcer healing rate and Hp eradication rate in treatment group were 75.90％ and 90.36％,respectively,which were significantly higher than those in control group (61.45％ and 78.31％) (P<0.05). After treatment,SF-36 score was significantly increased in both groups,but SCL-90 score was significantly decreased (P<0.05). After treatment,the improvement of SF-36 score and SCL-90 score in treatment group was better than that in control group (P<0.05). After treatment,PGI,PGR and G-17 in two groups were lower than before,while serum PGE2 level was higher than before (P<0.05). After treatment,the improvement of serum gastric function index and PGE2 level in treatment group was better than that in control group (P<0.05). Conclusion Anweiyang capsule combined with sucralfate suspension gel has good clinical effect in treatment of gastric ulcer,and can effectively promote the eradication of Hp and relieve symptoms,improve the function of gastric mucosa,which can facilitate ulcer healing and physical and mental recovery of patients.
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