Clinical study on adalimumab combined with methotrexate and hydroxychloroquine sulfateand in treatment of rheumatoid arthritis
Objective To explore the clinical effect of adalimumab combined with methotrexate and hydroxychloroquine sulfateand in treatment of rheumatoid arthritis. Methods Patients (100 cases) with rheumatoid arthritis in Suzhou Hospital of Anhui Medical University from January 2022 to February 2024 were divided into control (50 cases) and treatment (50 cases) group based on different treatments. Patients in the control group were po administered with Methotrexate Tablets,10 mg/time,once weekly,and they were po administered with Hydroxychloroquine Sulfate Tablets,0.2 g/time,twice daily. Patients in the treatment group were subcutaneous injection administered with Adalimumab Injection on the basis of the control group,40 mg/time,once every two weeks. Patients in two groups were treated for 12 weeks. After treatment,the clinical evaluations were evaluated,the scores of SDAI and QLQ-C30,the levels of IgG,IgM,RF,IL-17,TNF-α and IL-6 in two groups before and after treatment were compared. Results After treatment,the clinical effective rate in the treatment group was 94.00％,which was significantly higher than that in the control group (78.00％,P<0.05). After treatment,the SDAI scores of patients in both groups were significantly decreased,the QLQ-C30 scores were higher than before treatment (P<0.05),and the SDAI scores and QLQ-C30 scores in the treatment group were significantly better than those in the control group (P<0.05). After treatment,the levels of IgG,IgM,RF,IL-17,TNF-α and IL-6 in two groups were lower than those before treatment (P<0.05),and the levels of indicators in the treatment group were significantly lower than those in the control group (P<0.05). Conclusion The combination of adalimumab combined with methotrexate and hydroxychloroquine sulfateand can effectively improve the condition of rheumatoid arthritis patients,alleviate their pain symptoms,and effectively reduce inflammatory factors,and the quality of life of patients has been improved.
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