Clinical study on Wangbi Capsules combined with Loxoprofen Sodium Tablets in treatment of rheumatoid arthritis
Objective To observe the therapeutic effect of Wangbi Capsules combined with Loxoprofen Sodium Tablets in treatment of rheumatoid arthritis. Methods A total of 101 patients with rheumatoid arthritis in Wuxi Hospital of Traditional Chinese Medicine from January 2021 to January 2023 were selected,and were divided into a control group (51 cases) and a treatment group (50 cases) using a random number table and sealed letter method. Patients of the control group orally took Loxoprofen Sodium Tablets,1 tablets/time,3 times daily. On this basis,patients in the treatment group orally took Wangbi Capsules,4 tablets/time,3 times daily. Patients of two groups were treated for 3 months. The clinical efficacy,joint tenderness,number of swelling,immune indicators,serum factors,and serum inflammatory factors were compared between two groups. Results After treatment,the total effective rate (96.00％) of the treatment group was higher than 82.35％ of the control group (P<0.05). After treatment,the number of joint tenderness and swelling in both groups decreased (P<0.05),and the number of joint tenderness and swelling in the treatment group was less than that in the control group (P<0.05). After treatment,peripheral blood T helper cell 17 (Th17),Th17/Treg ratio,ESR,levels of serum CRP,RF,anti-CCP,IL-6,and TNF-α in both groups were decreased,while regulatory T cells (Treg) were increased (P<0.05). The peripheral blood Th17),Th17/Treg ratio,ESR,levels of serum CRP,RF,anti-CCP,IL-6,and TNF-α in the treatment group were lower than those in the control group,while Treg levels were higher than those in the control group (P<0.05). Conclusion The combination of Wangbi Capsules and Loxoprofen Sodium Tablets has shown good efficacy in treating rheumatoid arthritis,effectively reducing joint tenderness and swelling,and improving immune function and inflammatory response.
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