Clinical study on fluconazole combined with naftifine hydrochloride and ketoconazole in treatment of fungal diseases of external auditory canal
Objective To investigate the efficacy of Fluconazole Injection combined with Naftifine Hydrochloride and Ketoconazole Cream in treatment of fungal diseases of the external auditory canal. Methods A total of 122 ears were selected from 108 patients of fungal diseases with external auditory canal mycosis treated in the First Affiliated Hospital of Zhengzhou University from April 2021 to March 2024. Patients were divided into control group (54 cases,62 ears) and treatment group (54 cases,60 ears) according to random number table method. In the control group,Naftifine Hydrochloride and Ketoconazole Cream was applied to the affected area of the external ear canal,2 fingertip units each time,once daily. Patients in the treatment group was given Fluconazole Injection on the basis of control group,5 drops/ear per time,6 times daily. Both groups were treated for 14 d. The clinical efficacy,symptom disappearance time,hearing level,and serum indicator levels were compared between two groups. Results The total effective rates of the treatment group and the control group were 96.30％ and 83.33％ of,and the difference was statistically significant between the groups (P<0.05). The disappearance time of ear itching,ear pain,and swelling in the treatment group was shorter than that in the control group (P<0.05). After treatment,the auditory threshold of ear air conduction,PCT,SAA,and TNF-α levels in both groups was lower than those before treatment (P<0.05),and these indexes in the treatment group were lower than those in the control group (P<0.05). Conclusion Fluconazole Injection combined with Naprofen Ketoconazole Cream can improve the efficacy of fungal diseases of external auditory canal,alleviate clinical symptoms,improve hearing status,and reduce inflammatory reactions.
Fluconazole InjectionNaftifine Hydrochloride and Ketoconazole Creamfungal disease of the external auditory canalear bone conduction hearing thresholdPCTSAA
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