Quetiapine adverse event analysis based on real-world data
Objective To analyze adverse drug event signals of quetiapine after marketing,and to provide references for rational drug use. Mehtods The adverse drug event reports of quetiapine from January 2004 to March 2024 were collected by signal mining from FDA Adverse Drug Event Reporting System (FAERS) database. The adverse drug event signals of quetiapine were analyzed by ROR,PRR and BCPNN methods. Results A total of 75213 adverse drug event reports were screened out as the primary suspect drug. The proportion of females was higher than that of males,involving 27 system organ classes. The adverse drug event signals ranked in the top 30 signal frequencies included serotonin syndrome,and sleep apnoea syndrome. Among the top 30 adverse drug event signals,the fourth nerve disorder,parotitis,malignant pheochromocytoma and coma blisterwere were the new adverse drug events. Conclusion Quetiapine should be used before the evaluation of drug use and some new potential adverse events should be focused on.
quetiapineadverse drug eventsignal miningproportional imbalancereal-world dataserotonin syndromesleep apnoea syndrome
NETL
NSTL
万方数据
