Real-world study of adverse events associated with vericiguat based on FAERS
Objective To analyze the adverse drug events of vericiguat in the real world using FAERS database,and to provide reference for safe clinical medication. Methods The reporting odds ratio method and the proportional reporting ratio method were used to mine the adverse drug events data of vericiguat in the FAERS database from the first quarter of 2021 to the second quarter of 2024,with vericiguat as the primary suspected drugs. Classification and description of adverse drug events was conducted using the system organ class (SOC) and preferred term (PT) of the Medical Dictionary for Regulatory Activities. Common adverse drug events signals by above two methods were screened. Results A total of 692 cases of adverse drug events were obtained. Most patients were men,with the age of over 50 years old. The main sources of reported events were the United States and Japan. The reported events mainly occurred in 2022 and 2023. The main outcomes of reported events were death and hospitalization. Mining for vericiguat found that there were 11 SOCs and 23 PTs. Conclusion Based on the real-world data,this study comprehensively analyzed the adverse drug events characteristics in the actual clinical application of vericiguat,providing references for clinical use and related research.
vericiguatadverse drug eventFAERS databasedeathhospitalized
NETL
NSTL
万方数据
