槲皮素防治高尿酸血症的药理作用研究进展
Research progress on pharmacological effects of quercetin in preventing and treating hyperuricemia
唐芳 1何姗 1欧琴1
作者信息
- 1. 重庆市大足区人民医院 内分泌科,重庆 402360
- 折叠
摘要
高尿酸血症是造成痛风关节炎的独立危险因素.临床治疗高尿酸血症主要是降酸剂,但长期使用具有一些严重的不良反应.槲皮素属于黄酮醇类化合物,具有多种药理作用,可通过降低尿酸产生、促进尿酸盐排泄、减轻炎症反应、降低氧化应激反应、调控肠道菌群、降低肾脏损伤发挥防治高尿酸血症的作用.总结了槲皮素防治高尿酸血症的药理作用研究进展,为槲皮素的临床应用提供依据.
Abstract
Hyperuricemia is an independent risk factor for gouty arthritis. The main clinical treatment for hyperuricemia is acid lowering agents,but long-term use has some serious adverse reactions. Quercetin belongs to flavonol compounds and has various pharmacological effects. Quercetin can prevent and treat hyperuricemia by reducing uric acid production,promoting urate excretion,alleviating inflammatory reactions,reducing oxidative stress reactions,regulating gut microbiota,and reducing kidney damage. This article summarizes the research progress on pharmacological effects of quercetin in preventing and treating hyperuricemia,providing support for the clinical application of quercetin.
关键词
槲皮素/高尿酸血症/尿酸产生/尿酸盐排泄/炎症反应/氧化应激反应/肠道菌群/肾脏损伤Key words
quercetin/hyperuricemia/uric acid production/urate excretion/inflammatory reaction/oxidative stress reaction/intestinal flora/kidney damage引用本文复制引用
基金项目
重庆市大足区科技发展项目(DZKJ2022JSYJ-KWXM1030)
出版年
2024
NETL
NSTL
万方数据