首页|槲皮素防治高尿酸血症的药理作用研究进展

槲皮素防治高尿酸血症的药理作用研究进展

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高尿酸血症是造成痛风关节炎的独立危险因素。临床治疗高尿酸血症主要是降酸剂,但长期使用具有一些严重的不良反应。槲皮素属于黄酮醇类化合物,具有多种药理作用,可通过降低尿酸产生、促进尿酸盐排泄、减轻炎症反应、降低氧化应激反应、调控肠道菌群、降低肾脏损伤发挥防治高尿酸血症的作用。总结了槲皮素防治高尿酸血症的药理作用研究进展,为槲皮素的临床应用提供依据。
Research progress on pharmacological effects of quercetin in preventing and treating hyperuricemia
Hyperuricemia is an independent risk factor for gouty arthritis. The main clinical treatment for hyperuricemia is acid lowering agents,but long-term use has some serious adverse reactions. Quercetin belongs to flavonol compounds and has various pharmacological effects. Quercetin can prevent and treat hyperuricemia by reducing uric acid production,promoting urate excretion,alleviating inflammatory reactions,reducing oxidative stress reactions,regulating gut microbiota,and reducing kidney damage. This article summarizes the research progress on pharmacological effects of quercetin in preventing and treating hyperuricemia,providing support for the clinical application of quercetin.

quercetinhyperuricemiauric acid productionurate excretioninflammatory reactionoxidative stress reactionintestinal florakidney damage

唐芳、何姗、欧琴

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重庆市大足区人民医院 内分泌科,重庆 402360

槲皮素 高尿酸血症 尿酸产生 尿酸盐排泄 炎症反应 氧化应激反应 肠道菌群 肾脏损伤

重庆市大足区科技发展项目

DZKJ2022JSYJ-KWXM1030

2024

现代药物与临床
天津药物研究院,中国药学会

现代药物与临床

CSTPCD
影响因子:1.179
ISSN:1674-5515
年,卷(期):2024.39(9)
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