Mechanism of Kuaiwei Tablets in treating chronic non-atrophic gastritis based on network pharmacology and molecular docking
Objective To study the mechanism of Kuaiwei Tablets in treating chronic non-atrophic gastritis based on the methods of network pharmacology and molecular docking technology.Methods The TCMSP database and HERB database were used to obtain the active ingredients and targets of Kuaiwei Tablets,and the disease targets of chronic non-atrophic gastritis were obtained from GeneCards and OMIM databases,and then took the common targets of Kuaiwei Tablets and chronic non-atrophic gastritis.PPI network of the common targets was analysed by STRING database,and GO and KEGG pathway enrichment were analysed by Metascape.AutodockTools was used for molecular docking of the key components and targets of Kuaiwei Tablets.Results A total of 152 active ingredients such as quercetin,kaempferol,glycoprotein,formononetin and so on,385 ingredient targets,1 082 targets of chronic non-atrophic gastritis and 112 common targets were obtained from the network pharmacological study.The core targets were TP53,TNF,Akt1,JUN,IL-1β,etc.GO analysis showed that BP(1 650 pieces)mainly involve positive regulation of cell migration,response to molecule of bacterial origin,and positive regulation of programmed cell death,etc.MF(141 pieces)mainly involved kinase binding,kinase regulator activity,and cytokine receptor binding,etc.CC(66 pieces)mainly involved extracellular matrix,membrane raft,and secretory granule lumen,etc.There were 188 pathways obtained in the KEGG enrichment analysis,mainly including pathways in cancer,fluid shear stress and atherosclerosis,IL-17 signaling pathway,proteoglycans in cancer,chemical carcinogenesis-reactive oxygen species,etc.The molecular docking results showed that the effective components of Kuaiwei Tablets and the core targets could combined stably.Conclusion Kuaiwei Tablets can work on CNAG through multi-components,multi-targets and multi-pathways to prevent its transformation to chronic atrophic gastritis.
NETL
NSTL
万方数据
