首页|响应面试验优化金银花浸膏的真空带式干燥工艺研究

响应面试验优化金银花浸膏的真空带式干燥工艺研究

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目的 优化金银花浸膏的真空带式干燥工艺。方法 将单因素试验和响应面试验法结合,确定考察金银花浸膏的相对密度、第 2 段加热温度、履带速率和布料速度 4 个影响因素,以金银花干浸膏的水分和绿原酸转移率的综合评分作为考察指标,对金银花浸膏的真空带式干燥工艺参数进行优化。结果 最优化工艺参数为第2 段加热温度为 90℃、浸膏相对密度为 1。27、履带速率 110 mm/min,布料速度为 1。6 L/h。结论 所得工艺耗时短、效率高,工艺稳定,可操作性强,为金银花工业化生产提供了参考。
Optimization of vacuum belt drying process for Lonicerae Japonicae Flos extract by response surface test
Objective To optimize of vacuum belt drying process for Lonicerae Japonicae Flos extract.Methods Single factor test combined with response surface tests were used.Four influencing factors as relative density of extract,two-stage heating temperature,track speed,and distribution speed were confirmed,and the comprehensive score of moisture content and chlorogenic acid transfer rate was used as the evaluation index to optimize of vacuum belt drying process.Results The optimized process parameters were as following:the two-stage heating temperature was 90℃,the relative extract density was 1.27,the track speed was 110 mm/min,and the distribution speed was 1.6 L/h.Conclusion The obtained process has short time consumption,high efficiency,stable process,and strong operability,providing a reference for the industrial production of Lonicerae Japonicae Flos.

Lonicerae Japonicae Flos extractvacuum belt drying processmoisture contentchlorogenic acid transfer rateresponse surface test

郭田甜、杨本官、张丽萍、房兆营、孙艳、庄会芳、刘震远、马庆文、毕艳艳、王永刚

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鲁南制药集团 经方与现代中药融合创新全国重点实验室,山东 临沂 276000

鲁南厚普制药有限公司,山东 临沂 276000

中药制药共性技术山东省工程研究中心,山东 临沂 276000

鲁南制药集团股份有限公司,山东 临沂 276000

鲁南贝特制药有限公司,山东 临沂 276000

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金银花提取物 带式真空干燥 水分 绿原酸转移率 响应面试验

山东省重点研发计划(重大科技创新工程)临沂市兰山区科技创新发展计划

2021CXGC0105082105

2024

现代药物与临床
天津药物研究院,中国药学会

现代药物与临床

CSTPCD
影响因子:1.179
ISSN:1674-5515
年,卷(期):2024.39(10)
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