Clinical study of Wuling Capsules combined with fluvoxamine in treatment of depression
Objective To explore the clinical efficacy of Wuling Capsules combined with fluvoxamine in treatment of depression.Methods A total of 97 patients with depression admitted to the Outpatient Department of Beijing Huairou Anjia Hospital from March 2023 to August 2023 were selected and divided into control group(48 cases)and treatment group(49 cases)according to random number table method.Patients in the control group were po administered with Fluvoxamine Maleate Tablets before going to bed,100 mg/time,once daily.Patients in the treatment group were po administered with Wuling Capsules on the basis of the control group,3 capsules/time,3 times daily.The treatment course of both groups was 6 weeks.The clinical efficacy of the two groups was observed.17 Hamilton Depression Scale(HAMD-17)scores at each time point(before treatment and 2,4,and 6 weeks after treatment),9 Patient Health Questionnaire(PHQ-9)and Asens Insomnia Scale(AIS)scores,serum levels of brain-derived neurotrophic factor(BDNF),Interleukin-18(IL-18),and intercellular adhesion molecule-1(ICAM-1)in two groups before and after treatment were compared.Results After treatment,the total effective rate of the treatment group was 95.92%,which was significantly higher than that of the control group(81.25%,P<0.05).After 2,4 and 6 weeks of treatment,HAMD-17 scores in both groups were lower than before treatment(P<0.05).The HAMD-17 score of the treatment group was lower than that of the control group after 2,4 and 6 weeks of treatment(P<0.05).After treatment,PHQ-9,DASS-21 and AIS scores in both groups were lower than before,but SF-36 scores were higher than before(P<0.05).After treatment:the improvement of PHQ-9,DASS-21,AIS and SF-36 scores in the treatment group was better than that in the control group(P<0.05).After treatment,serum BDNF levels were significantly increased in both groups,but serum IL-18 and ICAM-1 levels were significantly decreased(P<0.05).After treatment,the serum levels of BDNF,IL-18 and ICAM-1 in the treatment group were better than those in the control group(P<0.05).Conclusion Wuling Capsules combined with fluvoxamine can effectively improve the clinical efficacy of patients with depression,reduce inflammation and neuronal function damage,promote depression,anxiety and other adverse emotional experience relief,which can improve sleep and quality of life.
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