Clinical study on Wuling Capsules combined with enalapril in treatment of anxiety disorders
Objective To explore the clinical efficacy of Wuling Capsules combined with Milnacipran Hydrochloride Tablets in treatment of anxiety disorders.Methods 111 Patients with anxiety disorder in Shijiazhuang Eighth Hospital from April 2021 to March 2024 were divided into control group(56 cases)and treatment group(55 cases)according to random number table method.Patients of the control group were po administered with Milnacipran Hydrochloride Tablets,the initial dose was 1 tablet/time,and was adjusted to the maintenance dose after 1 week,2 tablets/time,2 times daily.Patients of the treatment group were given Wuling Capsules on the basis of the control group,3 capsules/time,3 times daily.Patients in two groups were treated for 2 months.The clinical efficacy,subjective anxiety degree and serum index level of two groups were compared.Results The total effective rate of the treatment group(94.55%)was higher than 82.14%of the control group,and the difference between the groups was significant(P<0.05).After treatment,SAS scores and HAMA scores of both groups were significantly decreased(P<0.05),and SAS scores and HAMA scores of the treatment group were lower than those of the control group(P<0.05).After treatment,NPY was significantly increased,but DA and 5-HT were significantly decreased in both groups(P<0.05).NPY in the treatment group was higher than that in the control group,but DA and 5-HT in the treatment group were lower than those in the control group(P<0.05).Conclusion Wuling Capsules combined with Milnacipran Hydrochloride Tablets can improve the therapeutic effect of anxiety disorders,reduce anxiety levels,and may be related to the regulation of neurotransmitter secretion.
NETL
NSTL
万方数据
