Clinical study on Wenxin Granules combined with creatine phosphate sodium in treatment of viral myocarditis
Objective To explore the efficacy of Wenxin Granules combined with Creatine Phosphate Sodium for injection in treatment of viral myocarditis.Methods 79 Patients with viral myocarditis admitted to Beijing Renhe Hospital from June 2022 to March 2024 were divided into a control group(40 cases)and a treatment group(39 cases)according to random number table method.Patients in the control group received intravenous infusion of Creatine Phosphate Sodium for injection,adding 1 bottle to 150 mL physiological saline and dripping it within 30-45 min,once daily.Patients of the treatment group were po administered with Wenxin Granules on the basis of the control group,1 bag/time,3 times daily.Patients of two groups were treated continuously for 4 weeks.The total effective rate,cardiac function indicators,and serum indicators of two groups of patients were compared.Results The total effective rate of the treatment group(94.87%)was higher than 80.00%of the control group,and there was a significant difference between the groups(P<0.05).LV-Tei and RV-Tei of both groups after treatment were smaller than those before treatment(P<0.05).LV-Tei and RV-Tei of the treatment group after treatment were smaller than those of the control group(P<0.05).After treatment,the serum levels of CK-MB,HMGB1,and IL-37 in both groups were lower than those before treatment,while the serum level of adropin in both groups was higher than those after treatment(P<0.05).The serum levels of CK-MB,HMGB1,and IL-37 in the treatment group were all lower than those in the control group,while the serum level of adropin in the treatment group was higher than that in the control group(P<0.05).Conclusion The combination of Wenxin Granules and Creatine Phosphate Sodium for injection can improve the efficacy of viral myocarditis,improve heart function,and reduce myocarditis damage.
Wenxin GranulesCreatine Phosphate Sodium for injectionviral myocarditisCK-MBHMGB1IL-37
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