Clinical observation on Naoxinqing Capsules combined with metoprolol in treatment of effort angina pectoris
Objective To investigate the clinical efficacy of Naoxinqing Capsules combined with metoprolol in treatment of effort angina pectoris.Methods Patients(110 cases)with effort angina pectoris in Nantong Haimen People's Hospital from June 2021 to June 2023 were randomly divided into control and treatment group,and each group had 55 cases.Patients in the control group were po administered with Metoprolol Succinate Sustained-release Tablets,23.75 mg/d.Patients in the treatment group were po administered with Naoxinqing Capsules on the basis of the control group,0.9 g/time,three time daily.Patients in two groups were treated for 2 month.After treatment,the clinical evaluations were evaluated,improvement of clinical symptoms,cardiac function status,blood rheology indexes,and blood lipid indexes in two groups before and after treatment were compared.Results After treatment,the total effective rate in the treatment group was 94.55%,significantly higher than 72.73%in the control group(P<0.05).After treatment,the duration and frequency of angina pectoris and total myocardial ischemic load in 2 groups were significantly decreased(P<0.05).And the duration and frequency of angina pectoris and total myocardial ischemic load were lower than those in control group(P<0.05).After treatment,the LVEDD was significantly decreased in both groups(P<0.05),while LVEF,SV,and 6 min walking distance was significantly increased in both groups(P<0.05).And LVEDD,LVEF,SV,and 6 min walking distance in treatment group were better than those in control group(P<0.05).After treatment,the plasma viscosity,whole blood high shear viscosity,whole blood low shear viscosity,and fibrinogen in the treatment group were lower than those in the control group(P<0.05).After treatment,the reduction was more significant in the treatment group than in the control group(P<0.05).After treatment,the levels of triglyceride(TG),total cholesterol(TC)and low density lipoprotein cholesterol(LDL-C)in both groups were significantly decreased,but the levels of high density lipoprotein cholesterol(HDL-C)were significantly increased(P<0.05),and the treatment group was significantly better than the control group(P<0.05).Conclusion Naoxinqing Capsules combined with metoprolol has good efficacy in treatment of effort angina pectoris,can effectively improve patients'clinical symptoms and enhance their cardiac function with good efficacy and safety.
Naoxinqing CapsulesMetoprolol Succinate Sustained-release Tabletseffort angina pectorisLVEDDLVEFSV6 min walking distance
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