Clinical study of Xinkening Capsules combined with clopidogrel in treatment of unstable angina pectoris
Objective To investigate the clinical efficacy of Xinkening Capsules combined with clopidogrel in treatment of unstable angina pectoris.Methods A total of 100 patients with unstable angina pectoris treated in Sun Simiao Hospital of Beijing University of Chinese Medicine from September 2020 to September 2023 were selected and divided into control group and treatment group according to random number table method,with 50 cases in each group.Patients in the control group were po administered with Clopidogrel Bisulfate Tablets,2 tablets/time,once daily.Patients in the treatment group were po administered with Xinkening Capsules on the basis of the control group,2 grains/time,three times daily.Both groups were treated continuously for 6 weeks.The clinical efficacy of the two groups were observed,and the duration and frequency of angina pectoris attacks before and after treatment,and the platelet aggregation rate induced by arachidonic acid(AA)and adenosine diphosphate(ADP)between the two groups,serum levels of hypersensitive C-reactive protein(hs-CRP),interleukin-6(IL-6),homocysteine(Hcy),vascular endothelial growth factor(VEGF),and endothelial vasoconstricting peptide-1(ET-1)in two groups before and after treatment were compared.Results After treatment,the total effective rate of the treatment group was 94.0%,which was significantly higher than that of the control group(78.0%,P<0.05).After treatment,the duration and frequency of angina pectoris attacks in both groups were significantly decreased(P<0.05).After treatment,the duration and frequency of angina pectoris in the treatment group were lower than those in the control group(P<0.05).After treatment,the platelet aggregation rate induced by AA and ADP was significantly decreased in both groups compared with that before treatment(P<0.05).After treatment,the platelet aggregation rate in treatment group was lower than that in control group(P<0.05).After treatment,the levels of hs-CRP,IL-6,Hcy and ET-1 in both groups were decreased compared with before treatment,but the levels of VEGF were increased(P<0.05).After treatment,the improvement of serum factor index in treatment group was better than that in control group(P<0.05).Conclusion Xinkening Capsules combined with clopidogrel has good effect in treatment of unstable angina pectoris,and can alleviate clinical symptoms,inhibit platelet aggregation,reduce inflammatory factors,which can improve vascular endothelial function with good safety.
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