Clinical study on Yindan Xintai Dropping Pills combined with nicorandil in treatment of microvascular angina
Objective To explore the clinical efficacy of Yindan Xintai Dropping Pills combined with nicorandil in treatment of microvascular angina.Methods Patients(126 cases)with microvascular angina in the Second People's Hospital of Yichang from April 2022 to April 2024 were divided into control(63 cases)and treatment(63 cases)group according to drug use.Patients in the control group were po administered with Nicorandil Tablets,1 tablet/time,three times daily.Patients in the treatment group were po administered with Yindan Xintai Dropping Pills,10 pills/time,three times daily.Patients in two groups were treated for 28 d.After treatment,the clinical evaluations were evaluated,the symptom relief time,and the levels of EDV,PSV,RI,PI,ET-1,IL-6,ESM-1 and hs-CRP in two groups before and after treatment were compared.Results After treatment,the clinical effective rate in the treatment group(98.41%)was significantly higher than that in the control group(84.13%,P<0.05).After treatment,the 6MWT and SAQ in two groups were significantly higher than those before treatment(P<0.05),and which in the treatment group were significantly higher than those in the control group(P<0.05).After treatment,EDV,PSV and PI in two groups were significantly higher than before treatment,but RI,ET-1,IL-6,ESM-1 and hs-CRP were significantly lower than before treatment(P<0.05),and the levels of hemodynamics and inflammatory factor indicators in the treatment group were significantly better than those in the control group(P<0.05).Conclusion The synergistic treatment of Yindan Xintai Dropping Pills and nicorandil can improve the symptoms of patients with microvascular angina,regulate hemorheological status,promote the enhancement of cardiac function,and weaken inflammatory reactions.
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