Clinical study on Jinshuibao Tablets combined with compound ipratropium bromide in treatment of acute exacerbation of chronic obstructive pulmonary disease
Objective To investigate the efficacy of Jinshuibao Tablets combined with Compound Ipratropium Bromide Solution for inhalation in treatment of chronic obstructive pulmonary disease.Methods 79 Patients with chronic obstructive pulmonary disease who visited Yixing People's Hospital from February 2022 to January 2024,and divide them into a control group(40 cases)and a treatment group(39 cases)using a random number table method.Patients in control group received Compound Ipratropium Bromide Solution for inhalation,2 sprays/time,4 times daily.Patients in the treatment group was given Jinshui Bao Tablets orally on the basis of control group,4 tablets/time,3 times daily.Patients in both groups were evaluated after 2 weeks of treatment.The therapeutic effect,symptom remission time,disease degree,lung function index,and serum index were compared between two groups.Results The total effective rate of the treatment group(94.87%)was higher than that of the control group(80.00%),and there was a significant difference between the groups(P<0.05).The relief time of wheezing,chest tightness,pulmonary rales,and sputum in the treatment group was lower than that in the control group(P<0.05).After treatment,CAT scores in both groups were lower than those before treatment,and CAT score of the treatment group was lower than that of the control group(P<0.05).After treatment,FVC/FEV1,MVV,and PEF of both groups were higher than those before treatment(P<0.05),and FVC/FEV1,MVV,and PEF of the treatment group was higher than those of the control group(P<0.05).After treatment,the serum levels of CC-16,IL-17A,and MMP-9 were significantly decreased in both groups(P<0.05).The serum levels of CC-16,IL-17A,and MMP-9 in the treatment group were lower than those in the control group after treatment(P<0.05).Conclusion Jinshuibao Tablets combined with Compound Ipratropium Bromide Solution for inhalation can improve the efficacy of COPD,enhance symptom improvement efficiency,control disease progression,improve lung function,alleviate inflammatory reactions.
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