Clinical study of Shenqi Changtai Mixture combined with Oral Rehydration Salts Powder(Ⅲ)in treatment of infectious diarrhea in children
Objective To explore the curative effect of Shenqi Changtai Mixture combined with Oral Rehydration Salts Powder(Ⅲ)in treatment of infectious diarrhea in children.Methods A total of 110 children with infectious diarrhea admitted to the Maternal and Child Health Hospital of Qinhuangdao City from January 2023 to December were selected as the study objects,and all children were divided into control group and treatment group according to random number table method,with 55 cases in each group.Patients in the control group were given Oral Rehydration Salts Powder(Ⅲ),firstly,a bag of Oral Rehydration Salts Powder(Ⅲ)was dissolved in 250 mL of warm water,adjusted at a dosage of 30-50 mL/kg according to the dehydration of the child,and was taken within 4 h,twice daily.Patients in the treatment group were po administered with Shenqi Changtai Mixture before meals on the basis of the control group,the initial dosage was 30 mL,and the maintenance dosage was 10 mL/time,3 times daily.Both groups were treated for 7 d.The clinical efficacy of the two groups was observed,and the time for clinical symptoms to disappear,the changes of intestinal flora and the levels of inflammatory factors(TNF-α,IL-10,and IL-15)before and after treatment were compared between two groups.Results After treatment,the total effective rate of treatment group was 98.18%,which was significantly higher than that of control group(87.27%,P<0.05).After treatment,the antipyretic time,antinausea time,antidiarrheal time and virus negative time in treatment group were significantly shorter than those in control group(P<0.05).After treatment,Lactobacillus and bifidobacterium were significantly increased in both groups,but enterobacterium was significantly decreased(P<0.05).After treatment,the improvement of intestinal flora in treatment group was better than that in control group(P<0.05).After treatment,the levels of TNF-α,IL-10 and IL-15 in two groups were significantly decreased compared with those before treatment(P<0.05).After treatment,the serum inflammatory factors in treatment group were significantly lower than those in control group(P<0.05).Conclusion Shenqi Changtai Mixture combined with Oral Rehydration Salts Powder(Ⅲ)is effective and safe in treatment of infectious diarrhea in children,and can reduce the level of inflammatory factors in children,regulate intestinal flora,and shorten the time of symptom disappearance.
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