Clinical study on Maren Pills combined with bifidobacterium triple viable bacteria in treatment of elderly chronic functional constipation
Objective To investigate the efficacy of Maren Pills combined with Live Combined Bifidobacterium,Lactobacillus and Enterococcus Capsules in treatment of elderly chronic functional constipation.Methods The data of 73 patients with elderly chronic functional constipation in Wuxi Hospital of Traditional Chinese Medicine from March 2021 to March 2023 were collected,and the patients were divided into control group(36 cases)and treatment group(37 cases)according to different medication regimens.Patients in the control group took Live Combined Bifidobacterium,Lactobacillus and Enterococcus Capsules orally,2 capsules/time,twice daily.Patients in the treatment group were given Maren Pills orally,1 pill/time,2 times daily on the basis of the control group.Patients in both groups were treated for 4 weeks.The efficacy,symptom relief time,gastrointestinal function,quality of life,as well as recurrence at 3-month follow-up were compared between the two groups of patients.Results The total effective rate of the treatment group was 94.59%,which was higher than 69.44%of the control group(P<0.05).The relief time of abdominal distension,anal distension,and defecation difficulty in the treatment group was shorter than those in the control group(P<0.05).After treatment,PAC-QOL scores of both groups were significantly decreased(P<0.05),and PAC-QOL scores of the treatment group were lower than those of the control group(P<0.05).After treatment,the serum levels of GAS,MTL,and SP in both groups were significantly increased(P<0.05).The serum levels of GAS,MTL,and SP in the treatment group were higher than those in the control group(P<0.05).At the 3-month follow-up,the recurrence rate of the treatment group was lower than that of the control group,with a statistical significant difference(P<0.05).Conclusion The combination of Maren Pills and Live Combined Bifidobacterium,Lactobacillus and Enterococcus Capsules in treatment of elderly chronic functional constipation can accelerate the relief of symptoms,improve the gastrointestinal function and quality of life of patients,reduce the recurrence rate,and have a significant effect.
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