Clinical study on Compound Muniziqi Granules combined with desloratadine in treatment of eczema
Objective To analyze the efficacy of the combination of Compound Muniziqi Granules and Desloratadine Citrate Disodium Tablets in treatment of eczema.Methods A study was conducted on 100 patients with eczema admitted to Suzhou Ninth People's Hospital from March 2021 to March 2023.They were divided into control group and treatment group using a random envelope method,with 50 patients in each group.Patients of the control group were po administered with Desloratadine Citrate Disodium Tablets,1 tablets/time,once daily.Patients of the treatment group were po administered with Compound Muniziqi Granules on the basis of the control group,1 bag/time,3 times daily.Patients in both groups were treated for 7 d.The total effective rate,skin lesions,quality of life,immune function,and inflammatory factors were compared between two groups.Results The total effective rate(86.00%)of the treatment group was higher than 68.00%of the control group(P<0.05).After treatment,EASI score and pruritus degree score decreased significantly(P<0.05),and EASI score and pruritus degree score in the treatment group were lower than those in the control group(P<0.05).After treatment,the levels of CD3+and CD4+in both groups increased,while the levels of CD8+in both groups decreased(P<0.05).The levels of CD3+and CD4+in treatment group were higher than those in the control group,but the levels of CD8+in treatment group was lower than that in the control group.After treatment,the serum levels of IL-6 and TNF-α in both groups were decreased,while the serum levels of IL-10 in both groups were increased(P<0.05).The serum levels of IL-6 and TNF-α in the treatment group were lower than those in the control group,while the serum levels of IL-10 in the treatment group were higher than those in the control group(P<0.05).Conclusion Compound Munizizi Granules combined with Desloratadine Citrate Disodium Tablets can effectively promote the recovery of skin lesions in eczema patients,improve the quality of life,enhance immune function and reduce inflammation.
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