Clinical observation of Jinhua Xiaocuo Pills combined with isotretinoin in treatment of severe acne
Objective To analyze the clinical effect of Jinhua Xiaocuo Pills combined with isotretinoin in treatment of severe acne.Methods Ninety-two patients with severe acne treated in Baiyin Central Hospital from January 2021 to August 2023 were selected and divided into control group and treatment group according to random number table method,with 46 cases in each group.Patients in the control group were po administered with Isotretinoin Soft Capsules,10 mg/time,twice daily.Patients in the treatment group were po administered with Jinhua Xiaocuo Pills on the basis of the control group,4 g/time,three times daily.Both groups were treated for 8 weeks.The clinical effects of the two groups were observed,and the changes of GAGS score,DASS-21 score,36-item health survey Summary Form(SF-36)score and skin physiological indexes of facial lesions were compared before and after treatment.Results After treatment,the total effective rate was 95.65%in the treatment group and 82.61%in the control group,with significant difference between the two groups(P<0.05).After treatment,GAGS scores and total scores in both groups were significantly decreased(P<0.05).After treatment,GAGS score in the treatment group was lower than that in the control group(P<0.05).After treatment,DASS-21 scores were significantly decreased,while SF-36 scores were significantly increased in both groups(P<0.05).The improvement of DASS-21 and SF-36 scores in the treatment group was more significant(P<0.05).After treatment,water content of stratum corneum was significantly increased,sebum content,transcutaneous water loss(TEWL)value and pH value were significantly decreased in both groups(P<0.05).After treatment,the improvement of skin physiological indexes in the treatment group was more significant(P<0.05).Conclusion Jinhua Xiaocuo Pills combined with isotretin has definite effect in treatment of severe acne,and can effectively reduce the manifestations of skin lesions,inhibit sebum secretion,promote the recovery of skin barrier function,and reduce the impact on the emotional state and quality of life of patients.
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