Clinical study on Meilu Xiaocuo Ointment combined with hydroxychloroquine sulfate in treatment of nasal rosacea
Objective To explore the treatment effect of Meilu Xiaocuo Ointment combined with hydroxychloroquine sulfate in treatment of nasal rosacea.Methods Patients(138 cases)with nasal rosacea in Beijing Chaoyang Hospital,Capital Medical University from March 2022 to April 2024 were divided into control(69 cases)and treatment(69 cases)group.Patients in the control group were po administered with Hydroxychloroquine Sulfate Tablets,0.2 g/time,twice daily.Patients in the treatment group were administered with Meilu Xiaocuo Ointment,3-4 times every day.Patients in two groups were treated for 8 weeks.After treatment,the clinical evaluations were evaluated,the symptom relief time,the scores of VISIA and Acne-QOL,and the levels of β-EP,IL-6,SP and TNF-α in two groups before and after treatment were compared.Results After treatment,the clinical effective rate in the treatment group was 97.10%,which was significantly higher than that in the control group(85.51%,P<0.05).After treatment,the time for symptoms to improve in the treatment group was significantly earlier than in the control group(P<0.05).After treatment,the VISIA score and Acne-QOL score in two groups were significantly higher than those before treatment(P<0.05),and the score in the treatment group was significantly higher than that in the control group(P<0.05).After treatment,the levels of β-EP,IL-6,SP,and TNF-α in two groups were significantly lower than those before treatment(P<0.05),and the levels of these serum factors in the treatment group were significantly lower than those in the control group(P<0.05).Conclusion The synergistic treatment of Meilu Xiaocuo Ointment combined with hydroxychloroquine sulfate can accelerate the recovery of facial acne lesions,effectively reduce the inflammatory response.
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