Clinical study of thalidomide combined with doxycycline in treatment of rosacea
Objective To investigate the clinical efficacy of Thalidomide Tablets combined with doxycycline in treatment of type Ⅰ and type Ⅱ rosacea.Methods A total of 80 patients with type Ⅰ,Ⅱ rosacea in Nanyang Central Hospital and The First Affiliated Hospital of Wannan Medical College(Yijishan Hospital)were included from January 2023 and June 2023 and divided into control group(40 cases)and treatment group(40 cases),respectively.Patients of the control group were po administered with Doxycycline Hyclate Tablets,0.1 g/time,twice daily.Patients of the treatment group were po administered with Thalidomide Tablets on the basis of the control group,50 mg/time,twice daily.Patients of both groups were treated for 2 months.The clinical efficacy,facial symptoms,and serum factor levels were compared between two groups.Results After treatment,the total effective rate of control group and treatment group was 70.00％and 90.00％,respectively,with significant difference between groups(P<0.05).The scores of facial erythema,telangiectasia,papules,pustules,and pruritus in two groups after treatment were significantly decreased(P<0.05).Compared with the control group,the scores of facial erythema,telangiectasia,papules,pustules,and pruritus in the treatment group were significantly decreased,with a statistical significance(P<0.05).After treatment,the serum levels of IL-17,TNF-α,and VEGF in two groups were significantly decreased,and the serum levels of IL-17,TNF-α,and VEGF in treatment group were significantly lower than those in the control group,with a statistical significance(P<0.05).Conclusion Thalidomide Tablets combined with Doxycycline Hyclate Tablets has a significant clinical efficacy in treatment of type Ⅰ,Ⅱ rosacea,and can obviously improve the facial symptoms of patients,and relieve the inflammatory state of the body.
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