Clinical study of triamcinolone combined with sulfadiazine silver in treatment of hypertrophic scars after burns
Objective To explore the clinical study of triamcinolone combined with sulfadiazine silver in treatment of hypertrophic scars after burns.Methods A retrospective analysis was performed on 98 patients with post-burn hypertrophic scar admitted to the Burn and plastic Surgery Clinic of Wuhan Third Hospital from September 2021 to January 2024.According to different treatment methods,the patients were divided into control group and treatment group,with 49 cases in each group.Patients in control group were given Sulfadiazine Silver Cream,applied to the wound directly,about 1.5 mm thickness,once daily.Patients in treatment group were given Triamcinolone Acetonide Acetate Injection on the basis of treatment of control group,injected into the base of the scar in a spot shape,and terminated the injection until the skin was slightly white,once 2 weeks.Both groups were treated continuously for 8 weeks.The clinical efficacy and improvement time of symptoms and signs of the two groups were observed.The changes of Vancouver Scar Scale(VSS)score,Reduced Post-Burn Health Scale(BSHS-B)score,interleukin-2(IL-2),transforming growth factor-β1(TGF-β1),vascular endothelial growth factor(VEGF)and tumor necrosis factor-α(TNF-α)before and after treatment were compared between two groups.Results After treatment,the total effective rate of treatment group was 97.96%,which was significantly higher than that of control group(81.63%,P<0.05).After treatment,the improvement time of skin pruritus,skin burning pain and skin flushing congestion in treatment group was significantly shorter than that in control group(P<0.05).After treatment,VSS score in two groups was significantly decreased compared with before treatment,but BSHS-B score was significantly increased(P<0.05).After treatment,VSS score and BSHS-B score in treatment group were better than those in control group(P<0.05).After treatment,the serum levels of TGF-β1,TNF-α,IL-2 and VEGF in two groups were significantly decreased compared with before treatment(P<0.05).After treatment,the levels of these inflammatory factors in treatment group were significantly lower than those in control group(P<0.05).Conclusion Triamcinolone combined with sulfadiazine silver has a good clinical effect in treatment of hypertrophic scars after burns,and can effectively improve the color and hardness of hypertrophic scar tissue,weaken the local inflammatory response of the body,effectively improve the life quality of patients,which has certain clinical application value.
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