Clinical study on Fukang Pills and carboprost tromethamine in treatment of postpartum uterine atony and hemorrhage
Objective To explore the therapeutic effect and safety of Fukang Pills and carboprost tromethamine in treatment of postpartum uterine atony and hemorrhage.Methods Patients(116 cases)with postpartum uterine atony and hemorrhage in the Fifth Affiliated Hospital of Zhengzhou University from September 2021 to September 2023 were divided into control and treatment group based on different treatments,and each group had 58 cases.Patients in the control group were iv administered with Carboprost Tromethamine Injection within the uterus,the first injection dose was 250 μg,if active bleeding was still seen 15 min later,250 μg was injected again,the total dose was controlled within 2 mg.Patients in the treatment group were po administered with Fukang Pills on the basis of the control group,the first time was 9 g,followed by 9 g 6 h apart,and then 9 g for twice daily.Patients in two groups were treated for 5 d.After treatment,the clinical evaluations were evaluated,the 24 h bleeding volume,hemostasis time,inpatient duration,serum 25-(OH)D,D-D,and TGF-β1 levels,postpartum uterus regression and adverse reactions in two groups before and after treatment were compared.Results After treatment,the total clinical effective rates of the control group and the treatment group were 86.21%and 96.55%,respectively,and the difference between the two groups was statistically significant(P<0.05).After treatment,the amount of bleeding in 24 h,hemostasis time,and hospital stay in the treatment group were significantly shorter than those in the control group(P<0.05).After treatment,the levels of serum 25-(OH)D and TGF-β1 of parturients in both groups were significantly increased,while the level of serum D-D was significantly reduced(P<0.05).And the levels of these indicators in the treatment group were better than those in the control group(P<0.05).After treatment,the sum of three uterine diameters and fundal height of parturients in both groups were significantly reduced,and which in the treatment group were significantly lower than those in the control group(P<0.05).During treatment,the incidence of adverse reactions(34.48%)in the control group was significantly higher than that(17.24%)in the treatment group(P<0.05).Conclusion The combination of Fukang Pills and carboprostaglandin tromethamine has a significant therapeutic effect on postpartum uterine atony and hemorrhage,which can not only significantly improve the bleeding symptoms of parturients and shorten hospital stay,but also promote uterine involution and the recovery of serological indicators.
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