Clinical study on Leyunning Granules combined with atosiban in treatment of late threatened abortion
Objective To observe the clinical curative effect of Leyunning Granules combined with Atosiban Acetate Injection in treatment of late threatened abortion.Methods A total of 100 patients with late threatened abortion in Handan Maternal and Child Health Hospital from March 2020 to December 2021 were selected and divided into random number table method,with 50 cases in each group.Patients of the control group was treated with Atosiban Acetate Injection,the initial dose was 6.75 mg,and the time of slow intravenous injection was>1 min,then Atosiban Acetate Injection 7.5 mg/mL was dissolved into 0.9%sodium chloride injection 405 mL,and continued intravenous infusion for 3 h,24 mL/h,then the intravenous infusion was continued for 45 h,8 mL/h.Patients in the treatment group was po administered with Leyunning Granules on the basis of the control group,5 g/time,3 times daily,and continued treatment for 14 d.The clinical efficacy,symptom score,uterine arterial hemodynamics,and serum cytokines were compared between two groups.Results The total effective rate(94.00%)in the treatment group was higher than 80.00%in the control group,with significant difference between two groups(P<0.05).After treatment,the scores of lumbar soreness,lower abdominal pain,and vaginal bleeding were decreased in both groups(P<0.05),and the scores of lumbar soreness,lower abdominal pain,and vaginal bleeding in the treatment group were lower than those in the control group(P<0.05).After treatment,PI and RI in both groups were significantly decreased(P<0.05),and PI and RI in the treatment group were lower than those in the control group(P<0.05).After treatment,the levels of IFN-γ and TNF-α were decreased,but the levels of IL-10 were increased(P<0.05).And the levels of IFN-γ and TNF-α in the treatment group were lower than those in the control group,but the levels of IL-10 in the treatment group were higher than those in the control group(P<0.05).Conclusion Leyunning Granules combined with Atosiban Acetate Injection has good effect and safety in treatment of late threatened abortion.It can effectively relieve symptoms of patients,improve uterine placental perfusion status,and reduce inflammatory response.
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