Clinical study of Zegui Longshuang Capsules combined with levofloxacin in treatment of chronic prostatitis
Objective To explore the clinical efficacy of Zegui Longshuang Capsules combined with levofloxacin in treatment of chronic prostatitis.Methods A retrospective case-control study was used to analyze the case data of 84 patients with chronic prostatitis admitted to Pinggu Hospital,Beijing Friendship Hospital Affiliated to Capital Medical University from February 2021 to November 2023.They were divided into control and treatment groups according to different treatment plans,and each group had 42 cases.Patients in the control group were po administered with Levofloxacin Tablets,0.5 g/time,once daily.Patients in the treatment group were po administered with Zegui Longshuang Capsules on the basis of the control group,2 grains/time,once daily.Two groups were treated for 28 d.The clinical efficacy of two groups was compared,and the clinical manifestation score,National Institutes of Health Chronic Prostatitis Syndrome Score(NIH-CPSI)score,Symptom Self-rating Scale(SCL-90)score and the levels of white blood cells(WBC)and lecitin bodies(SPL)in prostate massage fluid(EPS)were compared between the two groups before and after treatment.Results After treatment,the total effective rate of the treatment group was 95.24%,which was significantly higher than that of the control group(80.95%,P<0.05).After treatment,the scores of rapid urination,incomplete urination,urethral burning,perineal pain or discomfort,low abdominal pain or discomfort,lumbosacral pain or discomfort were significantly lower in 2 groups than before treatment(P<0.05).After treatment,the clinical performance score of the treatment group was lower than that of the control group(P<0.05).After treatment,NIH-CPSI and SCL-90 scores were significantly decreased in both groups(P<0.05).After treatment,NIH-CPSI and SCL-90 scores in the treatment group were significantly lower than those in the control group(P<0.05).After treatment,WBC in EPS was significantly decreased,but SPL level in EPS was significantly increased in both groups(P<0.05).After treatment,WBC and SPL levels in EPS in the treatment group were better than those in the control group(P<0.05).Conclusion Zegui Longshuang Capsules combined with levofloxacin has good clinical effect in treatment of chronic prostatitis,and can effectively inhibit prostatic inflammation,promote the reduction of clinical manifestations and the improvement of physical and mental health status of patients,which is worthy of popularization and application.
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