Clinical study on Shenling Baizhu Powder combined with pioglitazone in treatment of type 2 diabetes of spleen deficiency and dampness stagnation
Objective To explore the therapeutic effect and safety of Shenling Baizhu Powder combined with pioglitazone in treatment of type 2 diabetes with spleen deficiency and dampness stagnation.Methods Patients(113 cases)with type 2 diabetes of spleen deficiency and dampness stagnation in Wuhan Hospital of Traditional Chinese Medicine from December 2021 to December 2023 were divided into control(56 cases)and treatment(57 cases)group based on different treatments.Patients in the control group were po administered with Pioglitazone Hydrochloride Tablets before breakfast,30 mg/d,once daily.Patients in the treatment group were po administered with Shenling Baizhu Powder on the basis of the control group,6 g/time,three time daily.Patients in two groups were treated for 8 weeks.After treatment,the clinical evaluations were evaluated,the traditional Chinese medicine syndrome score and DSQL score,the levels of FBG,2 h PG,HbA1c,GDF-15,FFA and chemerin in two groups before and after treatment were compared.Results After treatment,the total clinical effective rates in the control group and the treatment group were 78.57%and 94.74%,respectively,and the difference between the two groups was statistically significant(P<0.05).After treatment,the TCM syndrome scores and DSQL scores of patients in two groups were decreased significantly(P<0.05),and the score in the treatment group decreased more significantly than that in the control group(P<0.05).After treatment,the levels of FBG,2 h PG,HbA1c,GDF-15,FFA and chemerin were significantly reduced in two groups(P<0.05),and the levels of these indicators in the treatment group decreased more significantly than in the control group(P<0.05).Conclusion Shenling Baizhu Powder combined with pioglitazone produced notably effective results in treating spleen deficiency and dampness accumulation type 2 diabetes mellitus,improving patient symptoms and quality of life while promoting serum marker recovery.
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