Clinical study on Kanggu Zengsheng Capsules combined with loxoprofen sodium in treatment of early knee osteoarthritis
Objective To explore the therapeutic effect of anti osteoproliferative capsule combined with loxoprofen sodium in treatment of early knee osteoarthritis.Methods Patients(106 cases)with early knee osteoarthritis in Nanjing Integrated Traditional Chinese and Western Medicine Hospital from March 2021 to December 2023 were randomly divided into control group(53 cases)and treatment group(53 cases).Patients in control group were po administered with Loxoprofen Sodium Tablets,60 mg/time,three times daily.Patients in treatment group were po administered with Kanggu Zengsheng Capsules on basis of control group,5 grains/time,three times daily.Patients in two groups were treated for 4 weeks.After treatment,the clinical evaluations were evaluated,Oxford Knee Function Assessment Scale(OKS)scores,Visual Analog Scale(VAS),gait status,serum inflammatory levels interleukin-6(IL-6),hypersensitive C-reactive protein(hs-CRP),and adverse reactions in two groups before and after treatment were compared.Results After treatment,compared with the total effective rates(84.91%)in the control group,the total effective rates(96.23%)in the treatment group was higher significant(P<0.05).Compared with those before treatment,OKS and VAS scores in the treatment group after treatment were lower significant(P<0.05).Compared with those before treatment,step speed and step length in the treatment group after treatment were higher significant(P<0.05),and step speed and step length in the treatment group were higher than those in the control group(P<0.05).After treatment,the levels of IL-6 and hs-CRP were significantly reduced in two groups(P<0.05),and the levels of these indicators in the treatment group decreased more significantly than in the control group(P<0.05).Conclusion Kanggu Zengsheng Capsules combined with loxoprofen sodium has a good therapeutic effect on in treatment of early knee osteoarthritis,which can significantly reduce pain,improve knee joint function and gait,reduce inflammatory reactions,and have fewer and milder adverse reactions.
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