Clinical study on tizanidine combined with lidocaine in treatment of postoperative pain syndrome of lumbar spine
Objective To explore the treatment effect of tizanidine combined with lidocaine in treatment of in lumbar spine surgery.Methods The clinical data of 96 patients with postoperative pain syndrome of lumbar spine treated in the First Affiliated Hospital of Zhengzhou University from May 2022 to May 2024 were selected and analyzed retrospectively.They were divided into control(48 cases)and treatment(48 cases)group based on different treatments.Patients in the control group were iv administered with Lidocaine Hydrochloride Injection,and taken lateral position,performed epidural space puncture,and continuously pumped 0.5%lidocaine at a pump speed of 4.2 mL/h to relieve pain.Patients in the treatment group were po administered with Tizanidine Hydrochloride Tablets on the basis of the control group,4 mg/time,twice daily.Patients in two groups were treated for 10 d.After treatment,the clinical evaluations were evaluated,the improvement time of symptoms and signs,the scores of ODI and VAS,the levels of β-EP,IL-6,PEG2 and IL-1 in two groups before and after treatment were compared.Results After treatment,the total effective rate in the treatment group was 95.83%,which was significantly higher than that in the control group(81.25%,P<0.05).After treatment,compared with the control group,the improvement time for waist pain,limb soreness,limb numbness,and limb skin paraesthesia in the treatment group was significantly shorter than that in the control group(P<0.05).After treatment,the ODI score and VAS score in two groups were significantly lower than that of before treatment(P<0.05),and the score in the treatment group were decreased more significantly than that in the control group(P<0.05).After treatment,serum β-EP levels were significantly increased in two groups,while IL-6,PEG2,and IL-1 levels were decreased significantly(P<0.05),and serum inflammatory factor levels improved more significantly in the treatment group(P<0.05).Conclusion The synergistic treatment of lidocaine hydrochloride and tizanidine can alleviate the symptoms and signs of lumbar pain,and significantly improve the degree of lumbar functional impairment.
Tizanidine Hydrochloride TabletsLidocaine Hydrochloride Injectionpostoperative pain syndrome of lumbar spineODIβ-EPPGE2
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