大黄素防治急性胰腺炎的药理作用研究进展
Research progress on the pharmacological effects of emodin in prevention and treatment of acute pancreatitis
周岚 1李均艳 2叶欣 3王雨辰4
作者信息
- 1. 常州市武进中医医院 护理部,江苏 常州 213161
- 2. 常州市武进中医医院 临床药学室,江苏 常州 213161
- 3. 常州市武进中医医院 普外科,江苏 常州 213161
- 4. 常州市武进中医医院 骨科,江苏 常州 213161
- 折叠
摘要
急性胰腺炎是最常见的胃肠道急重症,由于缺乏特效的药物,其发病率和死亡率均较高.大黄素是大黄中的主要有效成分,具有多种药理作用,可通过降低炎症反应、降低胰腺组织细胞凋亡、保护肠道屏障功能、降低氧化应激反应、调节免疫平衡、降低消化酶分泌多途径、多靶点控制急性胰腺炎的病情发展,减轻胰腺组织的损伤.总结了大黄素防治急性胰腺炎的药理作用研究进展,为大黄素的临床应用提供参考.
Abstract
Acute pancreatitis is the most common gastrointestinal acute and severe disease,but its incidence rate and mortality are high due to the lack of specific drugs.Emodin is the main active ingredient in Rhei Radix et Rhizoma and has various pharmacological effects.Emodin can control the progression of acute pancreatitis and alleviate pancreatic tissue damage by reducing inflammation response,decreasing pancreatic tissue cell apoptosis,protecting intestinal barrier function,reducing oxidative stress response,regulating immune balance,and lowering digestive enzyme secretion through multiple pathways and targets.This article summarizes the research progress on the pharmacological effects of emodin in prevention and treatment of acute pancreatitis,providing reference for the clinical application of emodin.
关键词
大黄素/急性胰腺炎/炎症反应/细胞凋亡/肠道屏障功能/氧化应激反应/免疫平衡/消化酶分泌Key words
emodin/acute pancreatitis/inflammatory response/cell apoptosis/intestinal barrier function/oxidative stress response/immune balance/digestive enzyme secretion引用本文复制引用
基金项目
常州市武进区科技计划项目(WS201711)
出版年
2024
NETL
NSTL
万方数据