穿龙薯蓣皂苷防治再生障碍性贫血的药理作用研究进展
Research progress on pharmacological action of Dioscorea nipponica saponins in preventing and treating aplastic anemia
王杰 1杨玉堂 2王晓旭 3李丽1
作者信息
- 1. 山东第一医科大学附属省立医院 临床医学检验部,山东 济南 250021
- 2. 山东第一医科大学附属省立医院 儿科,山东 济南 250021
- 3. 山东第一医科大学附属省立医院 病理科,山东 济南 250021
- 折叠
摘要
再生障碍性贫血是一种以全血细胞减少、骨髓衰竭为特征的血液免疫功能障碍,其中免疫抑制疗法是最常用的治疗方案.穿龙薯蓣皂苷的结构类似于类固醇激素,具有多种药理作用,可通过增强骨髓增生活性、调节免疫平衡、抑制骨髓细胞凋亡、阻止骨髓细胞成脂化、促进血管新生、降低炎症反应以促进骨髓造血功能恢复,提高有核细胞数量,恢复血象指标水平.总结了穿龙薯蓣皂苷防治再生障碍性贫血的药理作用研究进展,为穿龙薯蓣皂苷的临床应用提供支持.
Abstract
Aplastic anemia is a blood immune dysfunction characterized by a decrease in whole blood cells and bone marrow failure,and immunosuppressive therapy is the most commonly used treatment method.Dioscorea nipponica saponins has a structure similar to steroid hormones and has multiple pharmacological effects.Dioscorea nipponica saponins can enhance bone marrow proliferation activity,regulate immune balance,inhibit bone marrow cell apoptosis,prevent bone marrow cell lipidation,promote angiogenesis,reduce inflammatory response to promote bone marrow hematopoietic function recovery,increase the number of nuclear cells,and restore blood count indicators.This article summarizes the pharmacological research progress of Dioscorea nipponica saponins in preventing and treating aplastic anemia,providing support for the clinical application of Dioscorea nipponica saponins.
关键词
穿龙薯蓣皂苷/再生障碍性贫血/骨髓增生/免疫平衡/细胞凋亡/成脂化/血管新生/炎症反应Key words
Dioscorea nipponica saponins/aplastic anemia/bone marrow proliferation/immune balance/cell apoptosis/lipidation/angiogenesis/inflammatory response引用本文复制引用
基金项目
济南市科技局临床医学科技创新计划项目(202004075)
出版年
2024
NETL
NSTL
万方数据