Mechanism of Biling Weitong Granules in treatment of functional dyspepsia based on network pharmacology and molecular docking
Objective To explore the mechanism of Biling Weitong Granules treating functional dyspepsia based on network pharmacology and molecular docking.Methods Effective components,targets and disease-related genes of Biling Weitong Granules and functional dyspepsia were collected through TCMSP,SymMap,SwissTargetPrediction,PharmMapper,UniProt and GeneCards databases.The"traditional Chinese medicine-component-intersection target"network diagram was constructed by Cytoscape 3.9.1 software,and the core compounds and targets in the network were screened.DAVID database was used for GO enrichment analysis and KEGG pathway analysis of intersection targets,and the key targets were verified by molecular docking.Results A total of 131 effective chemical components of Biling Weitong Granules were obtained,and 287 targets were used to treat functional dyspepsia.The core targets were SRC,CTNNB1,HSP90AA1,Akt1,STAT3.The molecular docking results showed that the five core targets were well combined with quercetin,obacunone,palmatine,and β-sitosterol in Biling Weitong Granules.Conclusion Biling Weitong Granules can inhibit the activation of the PI3K/Akt and MAPK signaling pathway,enhance gastrointestinal peristalsis,and infiltrate gastric mucosa to achieve the therapeutic effect of functional dyspepsia,providing reference for subsequent studies.
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