Clinical study on Qingke Pingchuan Granules in treatment of phlegm-heat obstructing lung syndrome of acute exacerbation of chronic obstructive pulmonary disease
Objective To evaluate the effectiveness of Qingke Pingchuan Granules in treatment of phlegm-heat obstructing lung syndrome of acute exacerbation of chronic obstructive pulmonary disease.Methods Patients(100 cases)with phlegm-heat obstructing lung syndrome of acute exacerbation of chronic obstructive pulmonary disease in Laixi People's Hospital and Qingdao Municipal Hospital from March 2022 to April 2023 were randomly divided into control(50 cases)and treatment(50 cases)group.Patients in the control group were administered with comprehensive treatment including routine care,oxygen therapy support,cough and asthma,and expectorant treatment.Patients in the treatment group were po administered with Qingke Pingchuan Granules,1 bag/time,three times daily.Patients in two groups were treated for 14 d.After treatment,the clinical evaluations were evaluated,the TCM syndrome scores,mMRC and CAT questionnaire scores,the levels of FEV1%,FEV1/FVC,6MWT,WBC and CRP in two groups before and after treatment were compared.Results After treatment,the total effective rate in the treatment group(98.00%)was significantly higher than that in the control group(86.00%,P<0.05).After treatment,the levels of WBC and CRP in two groups were significantly lower than that of before treatment(P<0.05),and the decrease in inflammatory indicators in the treatment group was more significant(P<0.05).After treatment,FEV1%,FEV1/FVC and 6MWT in two groups were significantly increased compared with before treatment(P<0.05),and the lung function and 6-minute walking distance in the treatment group were significantly better than those in the control group(P<0.05).After the 7th and 14th days of treatment,the TCM syndrome scores,mMRC and CAT questionnaire scores in two groups were significantly reduced(P<0.05),and the TCM syndrome scores,mMRC and CAT questionnaire scores of patients in the treatment group on the 7th and 14th days were significantly lower than those in the control group(P<0.05).Conclusion Qingke Pingchuan Granules can significantly improve clinical efficacy in the treatment of AECOPD(phlegm heat lung syndrome),demonstrating significant relief effects on typical symptoms such as cough,sputum production,chest tightness,and shortness of breath.It effectively promotes the recovery of lung functions,enhances their exercise tolerance,and significantly reduces the level of inflammatory markers.
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