Objective To explore the therapeutic effect of Qingre Bawei Capsules combined with oseltamivir in treatment of influenza.Methods Patients(104 cases)with influenza in Chongming Hospital Affiliated to Shanghai University of Medicine&Health Sciences from March 2022 to March 2024 were randomly divided into control(52 cases)and treatment(52 cases).Patients in were po administered with Phosphate Capsules,1 grain/time,twice daily.Patients in the were po administered with Qingre Bawei Capsules,3-5 grains/time,1-2 times daily.Patients in two 5 d.After treatment,the clinical evaluations were evaluated,the symptoms improved time,the levels of SOD,IL-6,IFN-γ and TNF-α in before and after compared.Results After treatment,the effective rate(96.15%)was higher(82.69%,P<0.05).After treatment,the improvement time of fever,headache,nasal congestion and body muscle soreness in the treatment group was shorter than that in the control group(P<0.05).After treatment,the levels of IL-6 and TNF-α were significantly decreased,but SOD and IFN-γ were increased in two groups(P<0.05).After treatment,the levels of IL-6 and TNF-α in the treatment group were lower than those in the control group,and the levels of SOD and IFN-γ were higher than those in the control group(P<0.05).Conclusion Qingre Bawei Capsules combined with oseltamivir in treatment of influenza can effectively alleviate cold symptoms,which can also improve cellular immune function and regulate the reduction of inflammatory factor content.