Clinical observation of Luohuazizhu Granules combined with cimetidine in treatment of upper gastrointestinal bleeding
Objective To explore the curative effect of Luohuazizhu Granules combined with Cimetidine Injection in treatment of upper gastrointestinal bleeding.Methods 86 Patients with upper gastrointestinal bleeding admitted to Taihe Hospital Affiliated to South Anhui Medical College from June 2022 to June 2023 were selected as the study subjects.Patients were divided into control and treatment groups according to the randomized envelope method,and each group had 43 patients.The control group was given intravenous infusion of Cimetidine Injection,and 2 mL Cimetidine Injection was diluted with 250 mL 5%glucose injection before intravenous infusion,once every 8 h.The treatment group were po administered with Luohuazizhu Granules based on control group,1 bag/time,4 times daily.Both groups were treated for 3 d.The clinical efficacy,rebleeding rate,improvement time of clinical symptoms,coagulation function indicators,and blood routine indicators between two groups were compared.Results After treatment,the total effective rate of the treatment group was significantly higher than that of the control group,but the rebleeding rate was lower than that of the control group(P<0.05).The hemostasis time,occult blood turning negative time,vomiting blood disappearance time,and abdominal pain relief time of the treatment group were shorter than those of the control group(P<0.05).After treatment,the levels of APTT,PT,TT,and FIB in both groups were significantly decreased(P<0.05),and these coagulation function indicators in the treatment group was lower than those in the control group(P<0.05).After treatment,the levels of Hb,RBC,and HCT in both groups were significantly increased(P<0.05),and blood routine indicators in the treatment group was higher than those in the control group(P<0.05).Conclusion Luohuazizhu Granules combined with Cimetidine Injection is better in treatment of upper gastrointestinal bleeding,with significant advantages in improving coagulation function,enhancing hemostatic effect,and reducing rebleeding rate.
万方数据
