Clinical study of Houtou Jianweiling Tablets combined with quadruple therapy in treatment of Helicobacter pylori positive chronic gastritis
Objective To investigate the therapeutic effect of Houtou Jianweiling Tablets combined with quadruple therapy in treatment of Helicobacter pylori(Hp)positive chronic gastritis.Methods A total of 160 patients with HP positive chronic gastritis admitted to Pudong Hospital of Fudan University and Shanghai Pudong New Area Yangjing Community Health Service Center from June 2021 to February 2024 were selected and divided into control group and treatment group according to random number table method,with 80 patients in each group.Patients in control group were given quadruple therapy,(1)they were po administered with Rabeprazole Sodium Enteric Capsules 0.5 h before breakfast and dinner,20 mg/time,twice daily.(2)They were po administered with Colloidal Bismuth Pectin Capsules 0.5 h before breakfast and dinner,200 mg/time,twice daily.(3)They were po administered with Amoxicillin Capsules after breakfast and dinner,1.0 g/time,twice daily.(4)They were po administered with Clarithromycin Tablets after breakfast and dinner,0.5 g/time,twice daily.(1)were administered for 4 weeks,(2),(3),(4)were administered for 2 weeks.Patients in treatment group were po administered with Houtou Jianweiling Tablets after meals on the basis of control group,4 tablets/times,3 times daily,for 4 weeks.Patients in two groups were treated for 4 weeks.The clinical efficacy,symptom disappearance time and Hp eradication rate of two groups were observed.The levels of Symptom Rating Scale(SCL-90),36-item health survey Summary Form(SF-36),serum gastric function(G-17,PG Ⅰ,PGⅡ)and inflammatory indicators(IL-1β,IL-8,CRP)before and after treatment were compared between two groups.Results After treatment,the total effective rate of treatment group was 97.50%,which was significantly higher than that of control group(88.75%,P<0.05).The disappearance time of upper abdominal pain,belching,acid reflux,abdominal distension,and nausea in treatment group was shorter than that in control group(P<0.05).The eradication rate of Hp in treatment group was 72.50%,which was significantly higher than 57.50%in control group(P<0.05).After treatment,SCL-90 score was significantly decreased in both groups,but SF-36 score was significantly increased(P<0.05).After treatment,the improvement of SCL-90 and SF-36 scores in treatment group was better than that in control group(P<0.05).After treatment,serum G-17 level was significantly increased,but serum PG-Ⅰ,PG-ⅠⅠ,CRP,IL-1β and IL-8 levels were lower than before treatment(P<0.05).After treatment,the improvement of serum gastric function and levels of CRP,IL-1β and IL-8 in treatment group was better than that in control group(P<0.05).Conclusion Houtou Jianweiling Tablets combined with quadruple therapy in treatment of helicobacter pylori(Hp)positive chronic gastritis can effectively accelerate the elimination of digestive tract symptoms,and can improve the eradication rate of Hp,promote inflammatory response and reduce gastric mucosal damage,and improve the mental health level and life quality to a great extent,which is worthy of clinical application.
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