Clinical study on Gongxuening Capsules combined with compound norethisterone in treatment of dysfunctional uterine bleeding
Objective To explore the clinical efficacy of Gongxuening Capsules combined with Compound Norethisterone Tablets in treatment of dysfunctional uterine bleeding.Methods 96 Patients with dysfunctional uterine bleeding in Wuxi Xishan People's Hospital from September 2021 to September 2023 were divided into control group and treatment group based on medication differences,with 48 cases in each group.The control group started taking orally Compound Norethisterone Tablets on the 5th day of the menstrual cycle,1 tablets daily.On this basis,the treatment group took orally Gongxuening Capsules,2 capsules per time,3 times daily.One course had 22 d,and two groups were treated for two courses.The clinical efficacy,TCM syndrome score,sex hormone level,coagulation function,and serological indicators were compared.Results The total effective rate of the treatment group was higher than that of the control group(P<0.05).After treatment,abdominal distension and pain score,lumbosacral soreness score,and mental fatigue score in both groups were decreased(P<0.05),and these TCM syndrome scores in the treatment group were lower than those of the control group(P<0.05).After treatment,FSH,LH,and E2 in both groups were decreased(P<0.05),and FSH,LH,and E2 in the treatment group were lower than those of the control group(P<0.05).After treatment,TT,PT,and APTT of the two groups were decreased(P<0.05),and TT,PT,and APTT of the treatment group were lower than those of the control group(P<0.05).After treatment,bFGF and PGF2α in two groups were increased,but Ang-II were decreased(P<0.05),and bFGF and PGF2α in the treatment group were higher than those of the control group,but Ang-II were lower(P<0.05).Conclusion The combination of Gongxuening Capsules and Compound Norethisterone Tablets has a definite therapeutic effect on dysfunctional uterine bleeding,which can alleviate clinical symptoms,regulate sex hormone levels and coagulation function,and improve serum cytokine levels.
Gongxuening CapsulesCompound Norethisterone Tabletsdysfunctional uterine bleedingabdominal distension and pain scoreFSHLHE2TTPTAPTTbFGFPGF2αAng-II
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