Clinical study on Jixiang Ankun Pills combined with drospirenone and ethinylestradiol in treatment of menstrual disorders of liver depression and qi stagnation
Objective Exploring the therapeutic effect of Jixiang Ankun Pills combined with drospirenone and ethinylestradiol in treatment of menstrual disorders of liver depression and qi stagnation.Methods Patients(122 cases)with menstrual disorders of liver depression and qi stagnation in Huairou Maternal and Child Health Care Hospital,Beijing Obstetrics and Gynecology Hospital of Capital Medical University from May 2022 to December 2023 were divided into control(61 cases)and treatment(61 cases)group based on different treatments.Patients in the control group were po administered with Drospirenone and Ethinylestradiol Tablets from the 5 d of menstruation and continuously for 21 d,1 tablet/time,once daily.Patients in the treatment group were po administered with Jixiang Ankun Pills,12 pills/time,twice daily.Patients in two groups were treated for 3 menstrual cycles.After treatment,the clinical evaluations were evaluated,the TCM syndrome score,ChQOL score,levels of hormone E2,LH and FSH,serum EGF,IL-1β and VEGF levels,and the recurrence rates in two groups before and after treatment were compared.Results After treatment,the total clinical effective rates in the control group and the treatment group were 85.25%and 96.72%,respectively,and the difference between the two groups was statistically significant(P<0.05).After treatment,the TCM syndrome scores in two groups were significantly decreased,while the ChQOL scores were significantly increased(P<0.05),and the scores in the treatment group improved more significantly than those in the control group(P<0.05).After treatment,the levels of E2,EGF and VEGF in two groups were significantly higher than before treatment,while the levels of LH,FSH and IL-1β were significantly lower(P<0.05),and the sexual hormone and serum levels in the treatment group were more significantly improved than those in the control group(P<0.05).After treatment,the recurrence rate within 6 months in the control group was 13.11%,which was significantly higher than that in the treatment group(1.64%),and the difference between the two groups was statistically significant(P<0.05).Conclusion The combination of Jixiang Ankun Pill and Quspirone ethinylestradiol tablets has a significant therapeutic effect on liver depression and qi stagnation type menstrual disorders.It can not only significantly improve the clinical symptoms,sex hormone levels,and quality of life,but also reduce the recurrence rate after discontinuation and promote the repair of serological indicators.
Jixiang Ankun PillsDrospirenone and Ethinylestradiol Tabletsliver depression and qi stagnationmenstrual disordersChQOL scoresex hormoneepidermal growth factorrecurrence rate
万方数据
