Clinical study on Shaofu Zhuyu Capsules combined with compound norethisterone in treatment of primary dysmenorrhea of cold coagulation and blood stasis
Objective To explore the clinical efficacy of Shaofu Zhuyu Capsules combined with compound norethisterone in treatment of primary dysmenorrhea of cold coagulation and blood stasis.Methods Patients(126 cases)with primary dysmenorrhea of cold coagulation and blood stasis in Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine from December 2022 to November 2023 were divided into control(63 cases)and treatment(63 cases)group according to random number table method.Patients in the control group were po administered with Compound Norethisterone Tablets from the 5 d of menstruation and continuously for 22 d until the next menstrual period,1 tablet/time,once daily.Patients in the treatment group were po administered with Shaofu Zhuyu Capsules,3 grains/time,three times daily.Patients in two groups were treated for 3 menstrual cycles.After treatment,the clinical evaluations were evaluated,the symptoms improved time,the scores of CMSS and VAS,the levels of pain mediators PGE2,β-EP,5-HT,and PGF2a,and the uterine microcirculation indexes RI,PI,and S/D in two groups before and after treatment were compared.Results After treatment,the total effective rate in the treatment group(96.83%)was higher than that in the control group(84.13%,P<0.05).After treatment,compared with the control group,the improvement time of abdominal pain,nausea,dizziness,cold limbs in treatment group was shortened(P<0.05).After treatment,the CMSS score and VAS score in two groups were significantly lower than before treatment(P<0.05),and compared with the control group,the score in the treatment group were decreased more significantly(P<0.05).After treatment,the levels of PGE2 and β-EP in two groups were significantly higher than before treatment,while the levels of 5-HT and PGF2a were significantly lower(P<0.05).After treatment,the levels of pain mediators in the treatment group were significantly better than those in the control group(P<0.05).After treatment,the uterine microcirculation index RI,PI,and S/D of patients in two groups were significantly lower than those before treatment(P<0.05),and index level of patients in treatment group was significantly lower than that in control group(P<0.05).Conclusion The combination therapy of Compound Norethisterone Tablets and Shaofu Zhuyu Capsules can improve the microcirculation of the uterus in a cold coagulation state,reduce the content of pain mediators in the body,and significantly improve dysmenorrhea symptoms.
Shaofu Zhuyu CapsulesCompound Norethisterone Tabletsprimary dysmenorrheacold coagulation and blood stasisCMSSpain mediatorsuterine microcirculation index
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