Clinical study of Compound Nanxing Zhitong Ointment combined with etoricoxib in treatment of cold-dampness arthralgia type knee osteoarthritis
Objective To explore the therapeutic effect of Compound Nanxing Zhitong Ointment combined with etoricoxib in treatment of cold-dampness arthralgia type knee osteoarthritis.Methods A total of 80 patients with cold-dampness arthralgia type knee osteoarthritis admitted to the Affiliated Hospital of Nanjing University of Chinese Medicine from March 2022 to May 2024 were selected and divided into control group and treatment group according to random number table method,with 40 cases in each group.Patients in control group were po administered with Etoricoxib Tablets,60 mg/time,once daily.Patients in treatment group were given Compound Nanxing Zhitong Ointment on basis of the control group,selected the most painful part,1 patch/time,1 time/every other day.Both groups were treated for 28 d.The clinical effects of two groups were observed,and the changes of WOMAC score,VAS score,SF 12 score,TCM symptom score,bone turnover markers and serum inflammatory factors before and after treatment were compared between two groups.Results After treatment,the total effective rate of treatment group was 95.00%,which was significantly higher than that of control group(77.50%,P<0.05).After treatment,WOMAC scores and VAS scores were significantly lower than before treatment,but SF-12 quality of life scores were higher than that before treatment(P<0.05).After treatment,WOMAC scores and VAS scores in treatment group were lower than those in control group,and SF-12 quality of life scores were higher than those in control group(P<0.05).After treatment,the scores of joint pain,local swelling,joint range of motion,waist and knee tenderness,joint heavy,cold aggravation,and stiffness in two groups were significantly lower than those before treatment(P<0.05),and the scores of TCM symptoms in treatment group were significantly lower than those in control group(P<0.05).After treatment,the levels of TPINP,β-CTX,and N-MID in two groups were significantly lower than those before treatment(P<0.05).The levels of TPINP,β-CTX,and N-MID in treatment group were significantly lower than those in control group(P<0.05).After treatment,the levels of TNF-α,IL-1,TGF-β1,and MMP13 in two groups were significantly lower than those before treatment(P<0.05).The levels of TNF-α,IL-1,TGF-β1,and MMP13 in treatment group were significantly lower than those in control group(P<0.05).Conclusion Compound Nanxing Zhitong Ointment combined with etoricoxib has obvious effect in treatment of cold-dampness arthralgia type knee osteoarthritis,and can significantly improve the joint function of patients,relieve pain,improve the life quality and bone metabolism of patients,and reduce inflammatory response,which is worth learning and applying.
Compound Nanxing Zhitong OintmentEtoricoxib Tabletscold and dampness impediment type knee osteoarthritisWOMAC scoreβ-CTXN-MIDTNF-αIL-1TGF-β1MMP13
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