Clinical study on Tongzhong'an Capsules and ganciclovir in treatment of pediatric herpetic stomatitis
Objective To explore the clinical efficacy of the combination of Tongzhong'an Capsules and Ganciclovir Tablets in treatment of pediatric herpetic stomatitis.Methods 86 Children with herpetic stomatitis admitted to Tianjin Teda Hospital from September 2021 to August 2024 were selected and divided into control group and treatment group according to the random number table method,with 43 cases in each group.The control group patients took Ganciclovir Tablets at a dose of 5 mg/kg,divided into three doses daily.On the basis of the control group,the treatment group was treated with external application of Zhongtong'an Capsules,3 times daily,apply 1 capsule of powder to the affected area each time,and maintained for at least 1 h.Two groups received continuous treatment for 14 d.The clinical efficacy,symptom disappearance,quality of life,and immunoglobulin levels were compared between two groups.Results The total effective rate of the treatment group(95.35%)was higher than 81.40%of the control group,and the difference between the groups was significant(P<0.05).The fever reduction time,pain relief time,herpes disappearance time,and ulcer disappearance time of the treatment group were all shorter than those of the control group(P<0.05).CDLQI scores of both groups was decreased(P<0.05),and CDLQI scores of the treatment group was lower than those of the control group(P<0.05).IgA,IgM,and IgE in both groups were increased after treatment(P<0.05),and these indexes in the treatment group were higher than those of the control group(P<0.05).Conclusion The combination of Zhongtong'an Capsules and Ganciclovir Tablets can improve the efficacy,improve clinical symptoms and immunoglobulin levels,and enhance quality of life.
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