首页|小儿泻速停颗粒联合枯草杆菌二联活菌治疗小儿急性感染性腹泻的临床研究

小儿泻速停颗粒联合枯草杆菌二联活菌治疗小儿急性感染性腹泻的临床研究

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目的 探讨治疗小儿小儿急性感染性腹泻,采用泻速停颗粒联合枯草杆菌二联活菌治疗的临床疗效。方法 选取2021 年 12 月—2024 年 3 月西北妇女儿童医院收治的 124 例患儿,随机数字法分为两组(对照组和治疗组),每组 62 例。对照组枯草杆菌二联活菌颗粒,1 袋/次,每日2 次。在对照组基础上,治疗组小儿泻速停颗粒,6 g/次,每日3 次。两组用药5 d 观察疗效,比较两组炎性因子水平、症状好转时间、免疫因子水平及药物不良反应。结果 治疗后,治疗组总有效率(96。77%)高于对照组的总有效率(85。48%,P<0。05)。治疗后,与对照组比较,治疗组呕吐、发热、腹痛、腹泻好转时间明显缩短(P<0。05)。治疗后,两组患儿血清免疫球蛋白G(IgG)、免疫球蛋白M(IgM)、免疫球蛋白A(IgA)指标均明显升高(P<0。05),且治疗组免疫因子指标明显高于对照组(P<0。05)。治疗后,两组患儿淀粉样蛋白A(SAA)、白细胞介素-6(IL-6)、内皮素-1(ET-1)、白细胞介素-17(IL-17)水平比治疗前低(P<0。05),且治疗组SAA、IL-6、ET-1、IL-17 水平低于对照组(P<0。05)。结论 枯草杆菌二联活菌与小儿泻速停颗粒协同治疗,可改善明显患儿感染性腹泻症状,提高患儿免疫系统能力。
Clinical study on Xiao'er Xiesuting Granules combined with Subtilis and Faecium Granules with,Live in treatment of acute infectious diarrhea in children
Objective To explore the clinical efficacy of Xiao'er Xiesuting Granules combined with Subtilis and Faecium Granules with,Live in treatment of acute in children.Methods Children(124 cases)with acute infectious diarrhea in Northwest Women and Children's Hospital from December 2021 to March 2024 were divided into treatment(62 cases)the random number table method.Children in the were po with Combined Bacillus Subtilis and Faecium Granules with,Live,1 bag/time.Children in the were po with Xiao'er Xiesuting Granules,6 g/time.Children were treated for 5 d.After treatment,the clinical evaluations were evaluated,the symptom relief time and the immune and inflammatory factor levels in two before and after treatment were.Results After treatment,the effective rate(96.77%)was significantly higher(85.48%,P<0.05).After treatment,the improvement time of vomiting,fever,abdominal pain,diarrhea in was significantly shortened(P<0.05).the IgG,IgM and IgA in two increased(P<0.05),and the immune factor were significantly higher(P<0.05).After treatment,the levels of SAA,IL-6,ET-1 and IL-17 in two lower than treatment(P<0.05),and the levels of inflammatory factors in the treatment lower than those in the control(P<0.05).Conclusion The synergistic treatment of Combined Bacillus Subtilis and Faecium Granules with,Live combined with Xiao'er Xiesuting Granules can significantly improve the symptoms of infectious diarrhea in children,enhance the immune system ability of children.

Xiao'er Xiesuting GranulesCombined Bacillus Subtilis and Enterococcus Faecium Granules with,Liveacute infectious diarrhea in childrenIgGIgASAAET-1

马晓娇、万凤凤、李虹

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西北妇女儿童医院 药剂科,陕西 西安 710061

西安市儿童医院 消化科,陕西 西安 710003

小儿泻速停颗粒 枯草杆菌二联活菌颗粒 小儿急性感染性腹泻 免疫球蛋白G 免疫球蛋白A 淀粉样蛋白A 内皮素-1

2024

现代药物与临床
天津药物研究院,中国药学会

现代药物与临床

CSTPCD
影响因子:1.179
ISSN:1674-5515
年,卷(期):2024.39(12)