Clinical observation of Xingpi Yang'er Granules combined with tolterodine in treatment of overactive bladder in children
Objective Exploring the efficacy of Xingpi Yang'er Granules combined with tolterodine in treatment of overactive bladder in children.Methods The clinical data of children(72 cases)with overactive bladder in Henan Children's Hospital from December 2022 to March 2024 were analyzed retrospectively.They were divided into control(36 cases)and treatment(36 cases)group based on different treatments.Children in the control group were po administered with Tolterodine Tartrate Tablets,1 mg/time for 5-9 years old children,2 mg/time for 10-12 years old children,twice daily.Children in the treatment group were po administered with Xingpi Yang'er Granules,6 g/time,twice daily.Children in two groups were treated for 14 d.After treatment,the clinical evaluations were evaluated,the 24 h voiding frequency,night voiding frequency,24 h urgency frequency,single voiding volume,the scores of OABSS and QOL,the levels of urinary flow dynamics indexes MCC,Qmax and PVR in two groups before and after treatment were compared.Results After treatment,the total clinical effective rates in the control group and the treatment group were 77.78%and 94.44%respectively,and the difference between the two groups was statistically significant(P<0.05).After treatment,the number of 24 h urination,night urination,and 24 h urgency urination were significantly reduced in two groups compared with before treatment,while the volume of single urination was significantly increased(P<0.05),and the improvement of each indicator in the treatment group was more significant than that in the control group(P<0.05).After treatment,the OABSS score and QOL score in two groups were significantly lower than before treatment(P<0.05),and the scores in the treatment group were more significantly lower than that in the control group(P<0.05).After treatment,the levels of urodynamic indicators MCC and Qmax in two groups were significantly higher than before treatment,while the level of PVR was significantly lower(P<0.05),and the level of urodynamic indicators in the treatment group was more significantly improved than that in the control group(P<0.05).Conclusion The combination of Xingpi Yang'er Granules and tolterodine has significant therapeutic effects on children with overactive bladder.It can not only significantly improve clinical symptoms such as urgency,frequency,and nocturia in children,but also improve their quality of life and promote the repair of urodynamic indicators.
Xingpi Yang'er GranulesTolterodine Tartrate Tabletsoveractive bladder in childrenOABSS scorePVRQmax
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