Objective To explore the clinical effect of Jiangtangning Capsules combined with rosiglitazone in treatment of type 2 diabetes.Methods 98 Patients with type 2 diabetes who received treatment in Shangluo Central Hospital from June 2018 to June 2021 were selected and divided into control group and treatment group according to random number table method,with 49 cases in each group.Patients in the control group were po administered with Rosiglitazone Hydrochloride Capsules,4 mg/d,and was given daily.Patients in the treatment group were po administered with Jiangtangning Capsules on the basis of the control group,2 g/time,3 times daily.Both groups were treated for 12 weeks.After treatment,the clinical efficacy was evaluated,2 h PG and other glucose metabolism indicators,HOMA-β,HOMA-IR,MAR,PV,HBV,LBV,RBP4,sICAM-1,APN,GDF-15 in two groups before and after treatment were compared.Results After treatment,the total effective rate of the treatment group was 95.9%,which was significantly higher than that of the control group(83.7%,P<0.05).After treatment,FPG,2 h PG,and HbA1c were significantly decreased in both groups(P<0.05).After treatment,the glucose metabolism index of the treatment group was lower than that of the control group(P<0.05).After treatment,HOMA-β was significantly increased,while HOMA-IR was significantly decreased in both groups(P<0.05).After treatment,the improvement of islet function indexes in treatment group was better than that in control group(P<0.05).Compared with before treatment,MAR and hemorheological parameters(PV,HBV,LBV)were significantly decreased in both groups after treatment(P<0.05).The decrease was more significant in the treatment group(P<0.05).After treatment,serum concentrations of RBP4,sICAM-1,and GDF-15 in both groups were significantly decreased compared with before treatment,but serum APN levels were significantly increased compared with those before treatment(P<0.05).After treatment,the serum levels of RBP4,sICAM-1,APN,and GDF-15 in treatment group were significantly improved compared with those in the control group(P<0.05).Conclusion Jiangtangning Capsules combined with rosiglitazone can obtain ideal blood glucose control effect in treatment of type 2 diabetes,and can further improve islet function and microcirculation,enhance endogenous protective effect,and protect vascular endothelial function,which is safe and worthy of clinical application.
Jiangtangning CapsulesRosiglitazone Hydrochloride Capsulestype 2 diabetes2 h PGHOMA-βHOMA-IRMARRBP4sICAM-1APN
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