Clinical observation of Yishen Huashi Granules combined with compound α-ketoacid in treatment of non-dialysis chronic kidney disease
Objective To investigate the therapeutic effect of Yishen Huashi Granules combined with compound α-ketoacid in treatment of non-dialysis chronic kidney disease.Methods A total of 86 patients with non-dialysis chronic kidney disease in the Second Affiliated Hospital of the Chinese University of Hong Kong(Shenzhen)from July 2021 to July 2024 were selected and divided into control group and treatment group according to the difference in drug use regimen,with 43 cases in each group.Patients in control group were po administered with Compound α-Ketoacid Tablets,5 tablets/time,three times daily.Patients in treatment group were po administered with Yishen Huashi Granules with warm water on the basis of the control group,1 bag/time,three times daily.Both groups were treated continuously for 4 months.The clinical efficacy and duration of clinical symptoms were observed,and the changes of renal function indexes,intestinal flora,exercise endurance and fatigue related indexes were compared between two groups.Results After treatment,the total effective rate of the treatment group was 86.05%,significantly higher than that of the control group(67.44%)(P<0.05).In the course of treatment,the disappearance time of edema,polyuria,hematuria,and low back pain in treatment group were significantly shorter than those in control group(P<0.05).After treatment,serum creatinine(Scr),uric acid(UA),blood urea nitrogen(BUN)and 24 h urinary protein quantity(24 h Upro)in two groups were significantly decreased compared with before treatment(P<0.05).After treatment,the renal function indexes of treatment group was lower than those of control group(P<0.05).After treatment,Escherichia coli in both groups was significantly lower than that before treatment,but Enterococcus faecalis,Bifidobacterium and Lactobacillus were significantly increased(P<0.05).After treatment,the improvement of intestinal flora in treatment group was better than that in control group(P<0.05).After treatment,anaerobic threshold(AT),peak oxygen uptake(VO2peak)and peak oxygen pulse(VO2/HRpeak)in both groups were significantly higher than those before treatment,but exercise endurance indexes and FACIT-F score were lower than those before treatment.The improvement of exercise endurance indexes and FACIT-F score in treatment group were better than those in control group(P<0.05).Conclusion Yishen Huashi Granules combined with compound α-ketoacid can increase the benefit of non-dialysis chronic kidney disease patients,and can alleviate clinical symptoms,improve renal function and exercise endurance,correct intestinal flora imbalance,reduce fatigue with high safety.
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