Literature analysis of adverse reactions to isavuconazole
Objective To analyze the clinical characteristics of adverse drug reactions caused by isavuconazole,and provide reference for the safe use of the drug in clinical practice.Methods Retrieve adverse drug reactions case reports and case series analysis related to isavuconazole from databases such as CNKI,Wanfang,VIP,PubMed,and Embase as of August 2024.Descriptive statistical analysis was conducted on patient general information,medication use,adverse drug reactions occurrence time,main clinical manifestations,treatment,and outcomes.Results A total of 15 articles were included in the study,involving 26 patients with a male to female ratio of 2.25∶1.The median age of the patients was 60(39,69)years old,and they mainly used therapeutic drugs for invasive fungal diseases of the lungs.The median time for adverse drug reactions occurrence was 10(4.8,17.5)d,and adverse reactions occurred within one month of medication in 20 patients(76.92%).A total of 39 adverse drug reactions occurred in 26 patients,with severe adverse reactions accounting for 26.92%,mainly due to various degrees of liver damage caused by medication.Adverse drug reactions affects a total of 11 systemic organs(SOC),with the top three being the nervous system,hepatobiliary system,and various laboratory abnormalities.The new adverse drug reactions(28.21%)is distributed among various SOC,and no obvious characteristics have been observed yet.24 patients recovering/recovered after treatment,with a median transition time of 7(2,10.25)d.Conclusion In clinical practice,it is necessary to understand the characteristics of adverse drug reactions caused by isavuconazole in various systems,and based on its possible mechanisms or epidemiological information,pay attention to high-risk populations that are prone to adverse drug reactions,in order to timely handle the risks encountered during medication.
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