Constipation-predominant irritable bowel syndrome is a disorder of gastrointestinal function,which is characterized by abdominal pain or abdominal discomfort with difficulty defecation,prolonged defecation time interval,and mental symptoms such as anxiety and depression.Secretagogues can be used to treat constipation-predominant irritable bowel syndrome,which can alleviate abdominal pain while treating constipation.There are currently three main types of secretagogues:chloride channel activators,guanylate cyclase C activators,and potent small molecule sodium/hydrogen exchanger 3 inhibitors.This article summarizes the mechanism,efficacy,and safety of secretagogues in treatment of constipation-predominant irritable bowel syndrome,in order to provide reference for clinical application.
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